Objective:To analyze the clinical effect of gastroscopy combined with laparoscopy in the treatment of gastric stromal tumors.Methods: From January 2015 to December 2017, 53 patients with gastric interstitial tumors were screened from the patients who were examined or admitted to our hospital. The patients who were not suitable for surgical treatment with gastroscopy and laparoscopy will be selected. As a control group, a total of 21 patients were treated with open surgery; the remaining 32 patients were treated as a study group with gastroscopy combined with laparoscopy. After treatment, analyze intraoperative or postoperative indicators, pathological results, risk of tumor recurrence, and incidence of complications.Results: The operation time in the study group was significantly longer than that in the control group. The blood loss, abdominal drainage volume, exhaust time, analgesic use time, and hospital stay in the study group were significantly shorter than those in the control group,P <0.05, and the differences were statistically significant. There was no difference between the immunohistochemical results and the benign and malignant tumor results in the group,P> 0.05, which was not statistically significant; the difference in recurrence risk between the study group and the control group was not significant,P> 0.05; the incidence of complications was significantly lower in the study group. In the control group, the difference was significant,P <0.05.Conclusion: Gastroscopy combined with laparoscopy for gastric stromal tumors has a significant effect, is safe and reliable, and is worthy of clinical promotion.