论文部分内容阅读
目的 :观察酒精性肝病大鼠肝细胞超微结构的变化。方法 :应用体视学的方法计量了实验性酒精中毒组大鼠 (5只 ,自由饮用 2 0 %的酒精 1 4周 )和对照组大鼠 (5只 ,自由饮用去离子水 1 4周 )肝细胞线粒体的体密度 (Vvm)、面密度 (Svm)、面数密度 (Nam)、比表面 (Qm)和规化形状因子 (RFFm) ;粗面内质网的体密度 (Vvr)、面密度 (Svr)。结果 :肝细胞 RFFm非常显著的减小 (P<0 .0 1 )、Vvm显著增加 (P<0 .0 5)、Nam呈增高趋势 (P<0 .0 5)。肝细胞 Vvr、Svr非常显著的降低 (P<0 .0 1 )。结论 :酒精中毒可导致肝细胞线粒体的畸形和增生 ;酒精中毒可引起肝细胞粗而内质网数量的减少 ,提示酒精可以引起肝细胞损伤并且可能是酒精性肝病的早期阶段。
Objective: To observe the changes of hepatocyte ultrastructure in alcoholic liver disease rats. Methods: The stereotactic method was used to measure the alcoholism rats (5 rats, 20% alcohol freely for 14 weeks) and the control rats (5 rats, free to drink deionized water for 14 weeks) Vvm, Svm, Nam, Qm and RFFm of hepatocyte mitochondria; Vvr of the rough endoplasmic reticulum, Density (Svr). Results: The RFFm of hepatocytes decreased significantly (P <0.01), Vvm significantly increased (P <0.05), and Nam increased (P <0.05). The Vvr and Svr of hepatocytes decreased significantly (P <0.01). Conclusions: Alcoholism can lead to deformity and hyperplasia of mitochondria in hepatocytes. Alcoholism can cause the reduction of the number of hepatocytes and endoplasmic reticulum, suggesting that alcohol can cause hepatocellular injury and may be an early stage of alcoholic liver disease.