通过菌斑涂片镜检及临床疗效观察,对比了牙周炎患者在口服与局部应用螺旋霉素加甲硝唑后牙周袋细菌的变化及临床表现。结果表明:口服与局部用药的近期疗效(3个月)无显著差异。局部用药可减少胃肠反应,降低用药成本。本文为观察局部应用该种抗菌药物的疗效及疗效维持时间提供依据。 Through the bacterial plaque smear microscopy and clinical observation, we compared the changes and clinical manifestations of bacteria in patients with periodontitis after oral and topical application of spiramycin and metronidazole. The results show that: the short-term efficacy of oral and topical application (3 months) no significant difference. Local medication can reduce gastrointestinal reactions, reduce medication costs. This article to observe the topical application of the antimicrobial efficacy and efficacy to provide the basis for the maintenance time.