山莨菪碱作为中药已广泛应用于国内的临床,关于它的作用机理,我们曾作过多次探讨,已经证明它能特异地与酸性磷脂结合,并能增加脂质体对Ca~(2+)的通透性,山莨菪碱能抑制肌质网Ca~(2+)-ATP酶和兔肾(Na~+-K~+)-ATP酶的活性,并能诱导心磷脂呈非双层结构。上述研究为揭示山莨菪碱的作用机理提供了十分有力的论据。最近,我们采用荧光偏振法和差示扫描量热法(DSC)首次报道山莨菪碱诱导酸性磷脂二棕榈酰磷脂酰甘油(DPPG)呈交插 Anisodamine has been widely used as a traditional Chinese medicine in clinical practice in China. We have made several discussions about its mechanism of action. It has been proved that it can specifically bind to acidic phospholipids and can increase liposome to Ca~(2+). ) The permeability of anisodamine can inhibit the activities of sarcoplasmic reticulum Ca~(2+)-ATPase and rabbit kidney (Na~+-K~+)-ATPase, and induce cardiolipin to be non-double-layered. structure. The above studies provide very strong arguments for revealing the mechanism of action of anisodamine. Recently, we reported for the first time that anisodamine-induced acid phospholipid dipalmitoyl phosphatidylglycerol (DPPG) was intercalated using fluorescence polarization and differential scanning calorimetry (DSC).