集落刺激因子(CSF)包含一组调节造血细胞生长和分化的相关糖蛋白,它的基因异常被认为与特异性造血性疾病有关。粒细胞巨噬细胞CSF(GM-CSF)在髓系细胞的生长和分化中起重要作用,还调节成熟细胞的功能活性。骨髓增生异常综合征(MDS)是一组克隆性造血异常疾病,易转化为急性白血病。本文检查了76例MDS[2例已转化为非淋巴细胞白血病(ANLL)]病人的GM-CSF基因结构。76例病人细胞遗传学分析,10例有5q~-染色体。用标准方法分别提取病人血和/或骨髓和4例健康对照者血标本的DNA,DNA用限制性内切酶HindⅢ Colony stimulating factor (CSF) contains a group of related glycoproteins that regulate hematopoietic cell growth and differentiation, and its genetic abnormalities are thought to be associated with specific hematopoietic disorders. Granulocyte macrophage CSF (GM-CSF) plays an important role in the growth and differentiation of myeloid cells and also regulates the functional activity of mature cells. Myelodysplastic syndrome (MDS) is a group of clonal hematopoietic disorders that predispose to acute leukemia. This article examined the GM-CSF gene structure in 76 patients with MDS [2 patients who have been converted to non-lymphoid leukemia (ANLL)]. 76 patients cytogenetic analysis, 10 cases have 5q ~ - chromosome. DNA of the blood samples of the patient’s blood and / or bone marrow and 4 healthy controls were separately extracted by standard methods. The DNA was digested with restriction endonuclease HindIII