作者报告了一例直肠癌患者接受全身化疗后出现脑膜瘤的坏死,导致临床神经病学恶化的病例。患者,男性,54岁,经腹手术切除了中分化直肠腺癌。既往有脑瘤病史10余年,无其它症状,神经病学检查正常,CT扫描证实大脑镰两侧一巨大脑膜瘤并颅骨增厚。直肠癌术后接受了2个周期5—Fu、甲酰四氢叶酸和左旋咪唑化疗,5—Fu和甲酰四氢叶酸静注,分别425mg/sqm及20mg/sqm,各连用5天。左旋咪唑口眼,50mg/8h连用3天。随后行骨盆放疗,再行第2次2个周期的化疗。于化疗2周(第一个周期)后,患者出现头痛、嗜睡、视乳头水肿和左侧偏瘫,强化CT和MRI示脑膜瘤中心出现新的低密度区。先行聚乙烯氯化物微粒颈 The authors report a case of rectal cancer with necrosis of meningioma after systemic chemotherapy, leading to clinical neurological deterioration. The patient, male, was 54 years old and had moderately differentiated rectal adenocarcinoma after abdominal surgery. The past had a history of brain tumors for more than 10 years, no other symptoms, neurological examination was normal, CT scan confirmed a large meningioma on both sides of the cerebral palsy and skull thickening. Rectal cancer received 2 cycles of 5-Fu, leucovorin and levamisole chemotherapy, 5-Fu and leucovorin intravenously, 425 mg/sqm and 20 mg/sqm, respectively, for 5 days each. Levo-imidazole mouth, 50mg/8h for 3 days. Followed by pelvic radiotherapy, and then the second 2 cycles of chemotherapy. After 2 weeks of chemotherapy (first cycle), the patient developed headache, lethargy, optic disc edema, and left hemiplegia. Enhanced CT and MRI showed a new low density area in the center of meningioma. Advance Polyvinyl Chloride Particles Neck