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本文报道用丙吡胺经食管心房调搏测定病窦及对照组的窦房结功能。结果发现用丙吡胺100mg,静注,10min后阿托品2mg静注或单用丙吡胺100mg静注,各项电生理指标无明显改变。先用阿托品2mg静注,10min后丙吡胺100mg静注或丙吡胺100mg静注,各项生理指标延长,病窦组的延长明显超过正常值。对照组的延长则不超过正常值。提示应用自主神经阻滞剂抑制丙吡胺的抗胆硷能作用后才显示其抑制窦房结的作用,因而病窦患者可以应用丙吡胺。
This article reports the use of disopyramide transesophageal atrial pacing determination of sinus and sinus node function. The results showed that with pyridine 100mg, intravenous injection, 10min atropine 2mg intravenously or intravenous injection of pyridine 100mg intravenously, the electrophysiological indicators did not change significantly. The first intravenous injection of atropine 2mg, 10min after intravenous injection of pyridine 100mg or pyridine 100mg intravenously, the physiological indicators of extended sick sinus group was significantly longer than normal. The extension of the control group does not exceed the normal value. Prompt application of autonomic blockers inhibit the anti-cholinergic effect of disopyramide showed its role in inhibiting the sinus node, and thus patients with sinus sick can be used pyridine.