论文部分内容阅读
目的研究双环醇片联合胸腺肽治疗慢性乙型肝炎的临床效果。方法随机选择141例慢性乙型肝炎病人分4组接受治疗,分别为:联合组,40例;双环醇组,38例;胸腺肽组,39例;空白组,24例。记录治疗前、治疗12周和治疗24周后血清谷丙转氨酶和谷草转氨酶水平及HBV-DNA定量、HBV-DNA阴转率的变化等。结果在治疗后12周和24周,联合组、双环醇组的谷丙转氨酶和谷草转氨酶水平有明显下降,较胸腺肽组和空白组有显著差异(P<0.05),但两组间无差异;在12周和24周之间无统计学差异。胸腺肽和联合组HBV-DNA下降和阴转率也高于空白组和双环醇组(P<0.05),但两组间无统计学差异。治疗12周后和24周后,联合组和胸腺肽组HBV-DNA下降,较双环醇组(0.99lg)和空白组(0.56lg)差异有显著性(P<0.05),两组间差异无统计学意义;12周和24周相比无统计学差异。在HBV-DNA的阴转率方面,在12周时,4组间相比无统计学意义,但在24周时,联合组和胸腺肽组的HBV-DNA阴转率较双环醇组和空白组有明显的统计学意义。结论双环醇片和胸腺肽联合应用治疗慢性乙型肝炎可有效降低谷丙转氨酶和谷草转氨酶,改善肝脏功能,同时保证抗病毒疗效,疗效较胸腺肽组未有下降。
Objective To study the clinical effect of bicyclic alcohol tablets combined with thymosin in the treatment of chronic hepatitis B patients. Methods A total of 141 patients with chronic hepatitis B were randomly divided into 4 groups and received treatment: 40 cases in combination group, 38 cases in bicyclic alcohol group, 39 cases in thymosin group and 24 cases in blank group. Serum alanine aminotransferase and aspartate aminotransferase levels, HBV-DNA quantitation and HBV-DNA negative conversion rate were recorded before treatment, 12 weeks after treatment and 24 weeks after treatment. Results The levels of alanine aminotransferase and aspartate aminotransferase in combination group and bicyclol group decreased significantly at 12 weeks and 24 weeks after treatment compared with thymosin group and blank group (P <0.05), but there was no difference between the two groups. There was no significant difference between 12 weeks and 24 weeks. Thymosin and combined group HBV-DNA decline and negative conversion rate was also higher than blank group and bicyclol group (P <0.05), but no significant difference between the two groups. After 12 weeks and 24 weeks of treatment, the HBV-DNA levels in combination group and thymosin group were significantly lower than those in bicyclol group (0.99 lg) and blank group (0.56 lg) (P <0.05), and no difference was found between the two groups Significance; 12 weeks and 24 weeks no significant difference. In terms of the negative conversion rate of HBV-DNA, there was no significant difference between the four groups at 12 weeks, but at 24 weeks, the negative conversion rate of HBV-DNA in the combined group and the thymosin group was higher than that in the bicyclic alcohol group and the blank group Significant statistical significance. Conclusion The combination of bicyclic alcohol tablets and thymosin in the treatment of chronic hepatitis B can effectively reduce alanine aminotransferase and aspartate aminotransferase, improve liver function, at the same time ensure the anti-virus efficacy, the therapeutic effect than the thymosin group did not decline.