论文部分内容阅读
Toll样受体(Toll-Like Receptor,TLR)配体脂多糖(Lipopolysaccharide,LPS),能诱导机体产生免疫耐受(或交叉耐受),其信号途径受到多种机制的精密调控,在天然免疫中扮演重要角色。microRNAs是Toll样受体通路中常见信号分子IL-1受体相关激酶(IRAK1、IRAK2)和肿瘤坏死相关因子6(TRAF6)的关键靶向元件,参与了免疫耐受(或交叉耐受)的建立及维持。本综述主要讨论了Toll样受体介导耐受形成的机制,并阐述其配体诱导的microRNAs的调节功能,看是否影响Toll样受体信号途径的激活以及内毒素耐受的建立、维持,对抗炎症疾病治疗的具有重要指导意义。
Toll-like receptor (TLR) ligand Lipopolysaccharide (LPS), can induce the body to produce immune tolerance (or cross tolerance), the signal path by a variety of mechanisms of precise control, in natural immunity Play an important role. MicroRNAs are key targeting elements of the common signaling molecules IL-1 receptor-associated kinases (IRAK1, IRAK2) and tumor necrosis factor 6 (TRAF6) in the Toll-like receptor pathway and are involved in immune tolerance (or cross-tolerance) Build and maintain. This review focuses on the mechanism of Toll-like receptor-mediated tolerance formation and elucidates the regulatory function of its ligand-induced microRNAs to see if it affects the activation of Toll-like receptor signaling and the establishment, maintenance, The treatment of inflammatory diseases has an important guiding significance.