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嘌呤与嘧啶受体 (P受体 )分为P1和P2受体两大类 ,P2受体包括P2X和P2Y受体。P2X进一步可分为P2X1,P2X2 ,P2X3 ,P2X4,P2X5,P2X6和P2X7亚型。P2X3 受体在感觉神经元中高度表达 ,在痛觉中发挥重要作用 ,异聚体P2X2 / 3 受体也涉及疼痛 ;P2Y受体的某些亚型在感觉神经元中高度表达 ,与痛觉有关。P2受体通过与其内源性配体核苷酸结合 ,参与机体组织器官多种功能的调节 ,在疼痛病理状态下 (如神经病理性痛、急性疼痛、炎性痛及内脏痛等 )发挥着重要的作用。P2受体有可能成为疼痛研究的新靶点。
Purine and pyrimidine receptors (P receptors) are divided into P1 and P2 receptors two categories, P2 receptors, including P2X and P2Y receptors. P2X is further divided into P2X1, P2X2, P2X3, P2X4, P2X5, P2X6 and P2X7 subtypes. P2X3 receptors are highly expressed in sensory neurons and play an important role in pain perception. Heterogeneous P2X2 / 3 receptors are also involved in pain; some subtypes of P2Y receptors are highly expressed in sensory neurons and are associated with pain sensation. P2 receptor plays an important role in the pathological conditions of pain (such as neuropathic pain, acute pain, inflammatory pain and visceral pain) through the regulation of various functions of tissues and organs by binding to its endogenous ligand nucleotides Role. P2 receptors may become a new target for pain research.