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为了对兼性细胞内细菌所致的肺部感染的治疗提供指导,作者通过对健康青年志愿受试者进行支气管肺泡灌洗所获得的肺泡巨噬细胞(AM)来研究该细胞对12种抗菌素的摄取。将人类 AM 置于放射标记的抗菌素中孵化2小时(所用抗菌素为利福平、盐酸氯林可霉素、盐酸林可霉素、氯霉素、四环素、头孢羟唑、红霉素、丙酸红霉素、苄基-青霉素钾、异烟肼、硫酸庆大霉素及乙胺丁醇),然后用特殊方法确定进入细胞的抗菌素量,所摄取的抗菌素以细胞内、外药物浓
To provide guidance on the treatment of bacterial infections of facultative cells in the lungs, the authors investigated alveolar macrophages (AMs) obtained by bronchoalveolar lavage of healthy young volunteers to investigate the effects of 12 antibiotics Ingestion. Human AM was incubated for 2 hours in radiolabeled antibiotics (rifampicin, clindamycin hydrochloride, lincomycin hydrochloride, chloramphenicol, tetracycline, cefotaxime, erythromycin, propionic acid Erythromycin, benzyl-penicillin potassium, isoniazid, gentamicin sulfate and ethambutol), and then determine the amount of antibiotics entering the cells using a special method, the antibiotics taken in intracellular and extracellular drug concentration