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目的：探讨丙型肝炎病人外周血单个核细胞（ＰＢＭＣ）对丙型肝炎病毒（ＨＣＶ）特异性抗原增殖反应与干扰素（ＩＦＮ）疗效关系。方法：用３Ｈ－ＴｄＲ掺入法研究１１例经ＩＦＮ治疗与１３例未经ＩＦＮ治疗病人ＰＢＭＣ的增殖反应以及ＨＣＶ－ＲＮＡ阴转和丙氨酸转氨酶（ＡＬＴ）复常指标。结果：１１例经ＩＦＮ治疗与１３例未经ＩＦＮ治疗病人ＰＢＭＣ对ＨＣＶ合成肽ＣＰ９、ＮＳ４增殖反应相比，前者明显增强，差异有显著性意义（Ｐ＜０．０５），且血清ＨＣＶ－ＲＮＡ阴转和ＡＬＴ复常分别达到３６．３６％（４／１１）和５５．５５％（５／９），明显高于未经ＩＦＮ治疗组。结论：ＩＦＮ治疗丙型肝炎可提高ＰＢＭＣ对ＨＣＶ抗原的增殖反应
Objective: To investigate the relationship between the proliferative response of hepatitis C virus (HCV) specific antigens and the efficacy of interferon (IFN) in peripheral blood mononuclear cells (PBMCs) of hepatitis C patients. Methods: The proliferative response and the indexes of HCV-RNA negative and alanine aminotransferase (ALT) in 11 patients with IFN and 13 without IFN were studied by 3H-TdR incorporation. Results: Compared with the proliferative responses of HCV synthetic peptides CP9 and NS4 in 11 patients treated with IFN and 13 patients without IFN, the former significantly increased (P <0.05), and the serum HCV-RNA 36.36% (4/11) and 55.55% (5/9) respectively were significantly higher than those without IFN treatment. Conclusion: IFN treatment of hepatitis C increases the proliferative response of PBMC to HCV antigens