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目的:研究大黄对胃肠道血流灌注的影响。方法:采用胃肠粘膜内pH值评估危重症患者胃肠粘膜的血流灌注情况,观察大黄的临床疗效并进行实验研究。结果:临床研究结果显示:脓毒症患者胃和直肠粘膜内pH值明显低于对照组(P<0.01),大黄能显著提高胃肠粘膜内pH值(P<0.01);大黄对应激性胃肠粘膜病变伴出血的有效率为73.4%。动物实验结果显示:大黄可提高失血性休克大鼠胃、小肠粘膜和肠系膜的血流量(P<0.01), 此外大黄尚能提高正常大鼠胃肠粘膜血流量(P<0.01)。结论:大黄能提高危重症患者和失血性休克大鼠胃肠粘膜的血流灌注。
Objective: To study the effect of rhubarb on gastrointestinal blood flow perfusion. Methods: The intra-gastrointestinal mucosal pH was used to evaluate the perfusion of gastrointestinal mucosa in critically ill patients. The clinical efficacy of rhubarb was observed and the experimental study was conducted. RESULTS: Clinical studies showed that the pH values in the gastric and rectal mucosa of patients with sepsis were significantly lower than those in the control group (P<0.01). Rhubarb could significantly increase the pH value in the gastrointestinal mucosa (P<0.01); The effective rate for stress gastrointestinal mucosal lesions with bleeding was 73.4%. The results of animal experiments showed that rhubarb can increase the blood flow of gastric mucosa, intestinal mucosa and mesentery in rats with hemorrhagic shock (P<0.01). In addition, rhubarb can still increase the blood flow of gastrointestinal mucosa in normal rats (P<0.01). . Conclusion: Rhubarb can increase the blood perfusion of gastrointestinal mucosa in critically ill patients and hemorrhagic shock rats.