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为评价锰接触对下丘脑－垂体－性腺轴的影响，选择健康男工１１２人，其中锰接触男工５８名（血锰２．１３±０．９５μｍｏｌ／Ｌ），非接触男工５４名（血锰１．４９±０．５９μｍｏｌ／Ｌ），以放射免疫法测定其血清ＦＳＨ、ＬＨ及睾酮。接触组平均血清睾酮浓度为２１．９４ｎｍｏｌ／Ｌ，明显低于对照组的２７．９７ｎｍｏｌ／Ｌ，而血清ＬＨ水平４．０２ＩＵ／Ｌ，明显高于对照组的３．２９ＩＵ／Ｌ；两组工人血清ＦＳＨ含量差异无显著性，分别为５．５３和５．７６ＩＵ／Ｌ。提示男工接触锰后，可影响下丘脑－垂体－睾丸分泌功能，引起血清睾酮和ＬＨ浓度的改变。
To evaluate the effect of manganese exposure on the hypothalamus-pituitary-gonadal axis, 112 healthy male workers were selected, including 58 male workers (2.13 ± 0.95 μmol / L) and 54 non-contact male workers Blood manganese 1.49 ± 0.59μmol / L), and its serum FSH, LH and testosterone were determined by radioimmunoassay. The average serum testosterone concentration in contact group was 21.94nmol / L, significantly lower than that in control group (27.97nmol / L), while the serum LH level was 4.02IU / L, which was significantly higher than that in control group (3.29IU / L) Serum FSH content was no significant difference, respectively 5.53 and 5.76IU / L. Prompted male workers contact with manganese, can affect the hypothalamus - pituitary - testis secretion, causing changes in serum testosterone and LH concentrations.