目的探讨血清降钙素原(PCT)在行血液透析置管引起的导管相关性感染诊断中的应用价值。方法采用免疫化学发光法检测导管相关性感染患者(75例)和非感染患者(400例)血清PCT和白细胞计数(WBC)水平,通过ROC曲线评价PCT和WBC指标对导管相关性感染的诊断价值。结果感染组患者血清PCT为(1.58±0.36)ng/ml,WBC水平为(7.53±0.67)×10~9/L,显著高于非感染组PCT为(0.11±0.08)ng/ml,WBC水平为(5.15±0.52)×10~9/L,差异具有统计学意义(P<0.05);ROC曲线分析显示,血清PCT和WBC的ROC曲线下面积(AUC)分别为0.845和0.512,并且PCT的AUC、诊断的敏感性(84.2%)及特异性(82.6%)均较WBC(敏感性:61.5%,特异性:30.7%)升高。结论血清PCT水平在血液透析导管相关性感染患者中明显升高,其对导管相关性感染的诊断具有较好的敏感性和特异性。 Objective To investigate the value of serum procalcitonin (PCT) in the diagnosis of catheter-related infections caused by hemodialysis catheterization. Methods The levels of serum PCT and WBC in patients with catheter-related infections (n ​​= 75) and non-infected patients (n = 400) were detected by immunochemiluminescence. The diagnostic value of PCT and WBC in the diagnosis of catheter-related infections . Results The PCT of the infected group was (1.58 ± 0.36) ng / ml, the WBC level was (7.53 ± 0.67) × 10 ~ 9 / L and significantly higher than that of the noninfected group (0.11 ± 0.08 ng / ml, (5.15 ± 0.52) × 10 ~ 9 / L, the difference was statistically significant (P <0.05). The ROC curve analysis showed that the area under the ROC curve of serum PCT and WBC were 0.845 and 0.512, respectively, AUC, diagnostic sensitivity (84.2%) and specificity (82.6%) than WBC (sensitivity: 61.5%, specificity: 30.7%) increased. Conclusions Serum PCT levels are significantly elevated in patients with hemodialysis-related ductal infections, which have a good sensitivity and specificity for the diagnosis of catheter-related infections.