肺以左右肺芽上皮为原基,在周围间充质内发育。其发育受到一系列复杂因素的影响,如内分泌、基因组、细胞与细胞间的相互作用等。其中以少数发育基因的表达最为重要,如Hox基因、Nmyc基因、Wnt基因等。这些发育基因的表达将顺次影响许多其它基因的表达,其基因表达的最终蛋白质产物决定了特异性细胞的表现型,进而影响肺的发育进程。 Lung lung bud epithelial around the original base, within the surrounding mesenchymal development. Its development is affected by a series of complex factors, such as endocrine, genome, cell-cell interactions and so on. Among them, the expression of a few developmental genes is the most important, such as Hox gene, Nmyc gene, Wnt gene and so on. The expression of these developmental genes will, in turn, affect the expression of many other genes whose final protein product of gene expression determines the phenotype of specific cells, which in turn affects the developmental process of the lungs.