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目的探讨丹参复合微乳(Co-ME)抗垂体后叶素致大鼠急性心肌缺血的药效。方法采用舌下静脉注射垂体后叶素造成心肌缺血的方法,检测丹参复合微乳和空白微乳、丹参酮微乳、丹酚酸微乳、丹参酮混悬液各给药组在注射垂体后叶素30min后血清中磷酸肌酸激酶(PCK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)的含量。结果丹参复合微乳、丹参酮微乳、丹酚酸微乳和丹参酮混悬液均可在一定程度上改善注射垂体后叶素诱导的急性心肌缺血,减少PCK、LDH活性及MDA的生成量、提高心肌组织SOD活性,且以丹参复合微乳疗效最为显著,具有优于丹参酮微乳、丹酚酸微乳的作用趋势,并优于丹参酮混悬液。结论微乳载药体系可明显促进丹参酮的吸收,提高生物利用度,对急性心肌缺血具有治疗作用,丹参酮和丹酚酸复合可增加疗效。
Objective To investigate the anti-pituitary-induced acute myocardial ischemia in Salvia miltiorrhiza composite microemulsion (Co-ME). Methods The method of sublingual intravenous injection of vasopressin to induce myocardial ischemia was used to detect the effects of Danshen composite microemulsion, blank microemulsion, tanshinone microemulsion, salvianolic acid microemulsion and tanshinone suspension on the posterior pituitary Serum levels of phosphokinase (PCK), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured after 30 min of exposure. Results Salvia miltiorrhiza composite microemulsion, tanshinone microemulsion, salvianolic acid microemulsion and tanshinone suspension could both improve the pituitrin-induced acute myocardial ischemia, decrease the activity of PCK and LDH and the production of MDA in a certain extent, Improve myocardial SOD activity, and the most significant Salvia composite microemulsion, has advantages over tanshinone microemulsion, salvianolic acid microemulsion role trend, and is superior to tanshinone suspension. Conclusion The microemulsion drug-loading system can significantly promote the absorption of tanshinone, improve the bioavailability, have a therapeutic effect on acute myocardial ischemia, and tanshinone and salvianolic acid can increase the curative effect.