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医学研究委员会(MRC)试验显示,通过积极治疗使成人第五相舒张压保持在≥90mmHg时,统计学上比安慰剂显然有益。但应强调,在如此规定的高血压下限时,其益处不大。在各种试验中主要效果是预防或纠正恶性期高血压;预防或缓解与高血压有关的心力衰竭;预防卒中;及延缓肾功能恶化速度。预防性抗高血压治疗显然不能防止冠状动脉病及其后果,尽管高血压
The Medical Research Council (MRC) trial showed statistically significant benefit over placebo when aggressive fifth-phase diastolic blood pressure was maintained at> 90 mmHg. However, it should be emphasized that there is little benefit in setting the lower limit of hypertension so defined. The main effects in various trials are prevention or correction of malignant hypertension; prevention or alleviation of heart failure associated with hypertension; prevention of stroke; and delay in the worsening of renal function. Prophylactic antihypertensive therapy clearly can not prevent coronary artery disease and its consequences, despite high blood pressure