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目的：观察右美托咪定预防腹腔镜胆囊切除术后恶心呕吐的临床效果。方法选择择期全麻下拟行腹腔镜胆囊切除术患者40例，将患者随机分为治疗组和对照组，每组20例，观察术后24h 出现恶心呕吐的情况。结果治疗组恶心呕吐发生率为15．0％明显低于对照组的55．0％，差异有统计学意义（P ＜0．05）。结论右美托咪定复合麻醉可显著降低腹腔镜胆囊切除术后恶心呕吐的发生率，值得临床推广使用。“,”Objective To observe the effects of dexmedetomidine to prevent nausea and vomiting after laparoscopic cholecystectomy. Methods 40 cases of patients undergoing laparoscopic cholecystectomy under general anesthesia were select-ed and randomly divided into treatment group and control group,with 20 cases in each group. The occurrence of nausea and vomiting was observed during 24 hours after operation. Results The incidence of nausea and vomiting in the treatment group (15. 0%)was significantly lower than that of the control group(55. 0%),the difference was statistically significant(P <0. 05). Conclusion Dexmedetomidine can reduce incidence of nausea and vomiting after laparoscopic cholecystectomy,and worthy of clinical use.