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心得安(Propranolol)为肾上腺素β-受体阻滞剂,具旋光性,其中左旋的具有β受体阻断作用,而无论左旋体和右旋体都具有直接膜稳定效应。心得安的化学结构式如图:自从心得安问世以来,临床上主要用于心律失常、心绞痛、高血压等疾病的防治。但从1973年Peterson等首次报告心得安在体外抑制精子活动后,心得安的抗生育作用逐渐受到重视,国外开展了动物实验和临床研究。目前国内尚未见这方面的研究报告。本文就心得安的抗生育作用、临床应用和作用机理作一简要综述。
Propranolol, an adrenergic beta-blocker, is optically active, with levorotatory blocking of beta receptors, with both immediate and dextrorotatory membrane stabilizing effects. Ambivalent chemical structure shown in Figure: Since the advent of peace of mind, the clinical mainly for arrhythmia, angina, hypertension and other diseases prevention and treatment. However, since Peterson et al. First reported in 1973 on the inhibition of sperm motility in vitro, propranolol has been paid more attention to anti-fertility and animal experiments and clinical studies have been carried out abroad. At present, there is no research report in this area. This article on the security of the role of anti-fertility, clinical application and mechanism for a brief review.