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嘉胃斯康是典型治疗胃食管返流病的海藻酸钠制剂。它在胃酸中可以形成一种漂浮的凝胶筏,较好地阻止胃食管返流。我们评价这个体系的指标有多种参数,如强度、体积、漂浮性、耐受力和弹性。另外,凝胶筏的强度还受许多因素影响,如分子量、M/G的比值。这两种参数是影响筏强度大小的内在因素。一些外在的因素如筏中钙离子的存在,包裹在筏中的二氧化碳数量。本文主要总结了如何评价凝胶筏,介绍了影响凝胶筏的因素,最后概括了海藻酸钠的降解情况及未来的进展。
Jia Weisi Kang is a typical treatment of gastroesophageal reflux disease sodium alginate preparations. It can form a floating gel rafts in gastric acid, better prevent gastroesophageal reflux. We evaluate the system’s indicators with a variety of parameters, such as strength, volume, buoyancy, endurance and elasticity. In addition, the strength of gel rafts is affected by many factors, such as molecular weight, M / G ratio. These two parameters are the internal factors that affect the strength of the raft. Some extrinsic factors such as the presence of calcium ions in the raft and the amount of carbon dioxide trapped in the raft. This article summarizes how to evaluate the gel raft, describes the factors that affect the gel raft, and finally summarizes the degradation of sodium alginate and its future progress.