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分析了70例妊娠期及哺乳期乳腺癌的治疗和预后因素,其中妊娠期乳腺癌32例,哺乳期乳腺癌38例;Ⅰ期11例,Ⅱ期43例,Ⅲ期16例。总的5a生存率为55.7%,根治术与改良根治术患者5a生存率分别为68.4%和62.5%,非根治术患者5a生存率为45.7%(P<0.05)。妊娠期及哺乳期乳腺癌与普通乳腺癌相比病期较晚,预后较差,相同病期和年龄患者的预后相同。治疗性终止妊娠和治疗后再次妊娠不影响预后(P>0.05)。结果表明,妊娠期及哺乳期乳腺癌的治疗和预后与同龄普通乳腺癌患者相同,首选治疗为改良根治术并根据患者不同情况辅以放射治疗、化疗或内分泌治疗,妊娠因素不能改变生存率
The treatment and prognostic factors of 70 cases of breast cancer during pregnancy and lactation were analyzed, including 32 cases of gestational breast cancer and 38 cases of breast cancer during breast-feeding period. There were 11 cases in stage I, 43 cases in stage II, and 16 cases in stage III. The overall 5-year survival rate was 55.7%. The 5-year survival rates of patients undergoing radical resection and modified radical resection were 68.4% and 62.5%, respectively. The 5-year survival rate was 45.7% in non-radical patients (P<0. 05). Pregnancy and breast-feeding breast cancer have a later stage of disease and poor prognosis compared with common breast cancer, and patients with the same disease stage and age have the same prognosis. Treatment termination of pregnancy and re-pregnancy after treatment did not affect the prognosis (P>0.05). The results showed that the treatment and prognosis of breast cancer during pregnancy and breastfeeding were the same as those of normal breast cancer patients of the same age. The preferred treatment was modified radical surgery and supplemented with radiotherapy, chemotherapy or endocrine therapy according to different conditions of the patient. Pregnancy factors did not change the survival rate.