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目的探讨米索前列醇预防产后出血的效果与价值。方法选择８６６例正常足月妊娠、单胎头位、自然临产阴道分娩者。随机分为观察组４３６例，在胎儿前肩娩出后立即舌下含化米索前列醇２００μｇ，对照组４３０例静脉注射催产素１０单位。观察第三产程时间、产后２ｈ出血量。结果两组第三产程时间分别为８．３７±３．３５ｍｉｎ和９．５０±３．９３ｍｉｎ，两组比较差异有显著性（Ｐ＜０．０５）；观察组产后２ｈ出血量（１３６．３±４３．５ｍｌ）与对照组（２１０．８±６２．１ｍｌ）相比较差异有显著性（Ｐ＜０．０５）。结论米索前列醇具有比催产素更强的子宫收缩作用，能有效地减少产后出血量，可替代催产素用于第三产程早期。
Objective To investigate the efficacy and value of misoprostol in preventing postpartum hemorrhage. Methods 866 cases of normal full-term pregnancy, single head position, spontaneous vaginal delivery. Randomly divided into observation group 436 cases, sublingual oxaliplatin 200μg sublingual immediately after the delivery of the anterior shoulder of the fetus, control group of 430 intravenous oxytocin 10 units. Observe the third stage of labor time, 2h postpartum hemorrhage. Results The duration of the third stage of labor was 8.37 ± 3.35min and 9.50 ± 3.93min in both groups, with significant difference between the two groups (P <0.05). The amount of bleeding at 2h after birth in the observation group (136.3 ± 43.5ml) compared with the control group (210.8 ± 62.1ml), the difference was significant (P <0.05). Conclusion Misoprostol has stronger uterine contractility than oxytocin and can effectively reduce the amount of postpartum hemorrhage. It can replace oxytocin for the early stage of the third stage of labor.