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目的 :检测慢性乙型肝炎 ( CHB)病人血清白细胞介素 -1 8( IL-1 8)、IFN-γ及白细胞介素 -4 ( IL-4 )水平 ,探讨 IL-1 8在 CHB发病机理中作用。结果 IL-1 8水平在 CHB重度、中度组明显高于正常对照组 ,轻度组与正常对照组相比无显著性差异 ,但有升高倾向 ,重度组 >中度组 >轻度组。 IFN-γ血清水平与 IL -1 8呈相应的变化 ,二者呈直线正相关。 IL -4水平在 CHB轻度组中最高 ,明显高于正常对照、CHB中度及重度组 ,后三组 IL-4水平无显著性差异。结论 :IL-1 8在 CHB的发病中有重要的作用
Objective: To detect the levels of serum interleukin-18 (IL-18), IFN-|Ã and interleukin-4 (IL-4) in patients with chronic hepatitis B (CHB) In the role. Results The level of IL-18 in CHB group was significantly higher than that in control group, but there was no significant difference between mild group and normal control group . IFN-γ serum levels and IL -1 8 showed a corresponding change, the two were linearly positive correlation. The level of IL-4 in CHB mild group was the highest, significantly higher than the normal control, CHB moderate and severe group, the latter three groups of IL-4 levels no significant difference. Conclusion: IL-18 plays an important role in the pathogenesis of CHB