目前文献报道的阴茎透明细胞癌起源于皮肤附属器的腺体。作者介绍了3例形态学独特的阴茎肿瘤,该肿瘤具有明显的透明细胞特点,但并非起源于阴茎皮肤,而是起源于龟头表面鳞状上皮的黏膜组织。作者对其临床及病理学特征进行分析。免疫组化检测GATA3及p16的表达。采用原位杂交法检测3例阴茎透明细胞癌的HPV表达情况,其中1例全组织切片进行聚合酶链反应。患者年龄分别为52、88 Currently reported in the literature of clear cell carcinoma of the penis originated in the gland of skin appendages. The authors introduced 3 cases of morphologically unique penile tumors, the tumor has a clear cell characteristics, but not originated in the penis skin, but originated in the squamous cell surface of the glans mucosa. The authors analyzed their clinical and pathological features. Immunohistochemistry was used to detect the expression of GATA3 and p16. In situ hybridization was used to detect HPV expression in 3 cases of clear cell carcinoma of the penis. One case of whole tissue sections was subjected to polymerase chain reaction. Patients were 52,88 years old