论文部分内容阅读
很多细胞因子都可影响人类的生殖过程,包括表皮生长因子(EGF)和白血病抑制因子(LIF)。EGF以自分泌和/或劳分泌调节卵泡发育且对颗粒细胞具有促有丝分裂作用,还可诱导子宫内膜的蜕膜增生和分化。在人类EGF可由植入前的胚胎产生,且在胚泡种植中发挥重要作用。在体外,EGF与滋养层细胞共同培养可显著提高其侵袭能力。子宫内膜中LIF对胚胎种植具有支持作用,并且还大大增加胚胎形成的机会。目前研究已证实,卵泡液中有LIF表达,且其表达受绒毛膜促性腺激素的影响。
Many cytokines can affect human reproductive processes, including epidermal growth factor (EGF) and leukemia inhibitory factor (LIF). EGF regulates follicular development by autocrine and/or secretory secretion and has a mitogenic effect on granulosa cells and also induces decidual hyperplasia and differentiation of the endometrium. Human EGF can be produced from pre-implantation embryos and plays an important role in blastocyst implantation. In vitro, EGF and trophoblast cells co-culture can significantly increase its invasive ability. LIF in the endometrium supports the implantation of embryos and also greatly increases the chance of embryonic development. Current studies have confirmed that LIF is expressed in follicular fluid and its expression is affected by human chorionic gonadotropin.