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以2,3,4-三甲氧基苯甲醛为原料,经4步反应合成了两个未见文献报道的1,2-苯并-α-吡喃酮类衍生物,其结构经NMR和MS确证。体外抗氧化性能测试结果显示,3-苯乙酰氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮在高浓度时显示出比对照品和3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮更好的DPPH自由基清除活性,在低浓度时则对羟自由基表现出比对照品及3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮更好的抑制活性,在ABTS自由基清除实验中,低浓度的3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮展现出较对照品更佳的清除活性,两者具有进一步研究的价值。
Two 2,3-trimethoxybenzaldehyde were used as starting materials to synthesize two unreported 1,2-benzo-α-pyrone derivatives in 4 steps. Their structures were confirmed by NMR and MS Confirmed. In vitro antioxidant test results show that 3-phenylacetamido-7,8-dimethoxy-1,2-benzo-α-pyranone shows a higher concentration than the reference substance and 3-amino-7 , 8-dimethoxy-1,2-benzo-α-pyranone showed better DPPH radical scavenging activity than the control and 3-amino-7, 8-dimethoxy-1,2-benzo-α-pyranone showed better inhibitory activity. In ABTS radical scavenging assay, low concentration of 3-amino-7,8-dimethoxy- , 2-benzo-α-pyranone showed better scavenging activity than the control, both of which have the value of further research.