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西地那非可抑制PDE5,增加cGMP介导的血管舒张,并可有效治疗肺动脉高压(PAH)。为此Pepke-Zaba J等人进行了一项双盲、安慰剂对照研究,研究入选278名PAH患者,给予患者口服西地那非(20,40,
Sildenafil inhibits PDE5, increases cGMP-mediated vasodilation, and is effective in treating pulmonary hypertension (PAH). To this end, Pepke-Zaba J et al. Conducted a double-blind, placebo-controlled study of 278 patients with PAH who were given sildenafil orally (20, 40,