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研究新生儿缺氧缺血性脑病(HIE)血糖、血中胰岛素样生长因子-1(IGF-1)的变化,为临床治疗HIE提供参考依据,并探讨对IGF-1在HIE发病机制中的作用。用放免法测定了48例HIE患儿生后第一天、第七天及40例正常新生儿生后第一天空腹外周静脉血IGF-1,同时用微量血糖仪测微量血糖。结果显示,与正常新生儿相比HIE患儿血糖显著升高(t=2.613 P<0.05),IGF-1则显著减低(t=4.933 P<0.05);不同程度的HIE血糖无明显变化(第1d F=0.714 P>0.05第7 d F=1.743P>0.05),IGF-1下降明显(第1 d F=9.004 P<0.05第7 d F=5.910 P<0.05);经直线相关分析证实HIE患儿血糖和IGF-1呈负相关(r=-0.353 P<0.05)。可以确认,IGF-1与HIE程度有关,在其发病机制中可能具有重要作用。
To study the changes of blood glucose and blood insulin-like growth factor-1 (IGF-1) in neonates with hypoxic-ischemic encephalopathy (HIE) and provide a reference for clinical treatment of HIE and to explore the role of IGF-1 in the pathogenesis of HIE effect. Radioimmunoassay was used to measure the fasting blood glucose (IGF-1) in 48 HIE children on the first day, the seventh day and 40 normal newborns on the first day after birth. The results showed that compared with normal newborns, HIE children had significantly higher blood glucose (t = 2.613 P <0.05) and IGF-1 (t = 4.933 P <0.05), while no significant changes in HIE blood glucose 1 d F = 0.714 P> 0.05 7 d F = 1.743P> 0.05), IGF-1 decreased significantly (1st day F = 9.004 P <0.05 7th day F = 5.910 P <0.05). The linear correlation analysis confirmed that HIE Children with blood glucose and IGF-1 was negatively correlated (r = -0.353 P <0.05). Confirmed that IGF-1 and HIE level, in its pathogenesis may play an important role.