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为建立多囊卵巢小鼠模型,分别给不同日龄(5,8,11,14,17,21日龄)昆明种小鼠注射1mg 睾酮,结果提示以5日龄以内的昆明种小鼠注射睾酮,制成排卵功能失调的动物模型最佳。在此基础上对2,5,8,11,14日龄昆明种小鼠进行睾酮处理,并将治疗月经失调病中常用补肾药分离成水溶和脂溶部分,给上述各组小鼠服药并作对照观察。结果2日龄组卵巢均为多囊卵巢;补肾药水溶部分使各日龄组子宫增重,使多囊卵巢内间质腺细胞肥大,使8日龄以上小鼠卵巢增重;补肾药脂溶部分则无以上作用。提示补肾药中水溶部分是调节卵巢功能的主要部分。
To establish a mouse model of polycystic ovary, 1 mg testosterone was injected into Kunming mice of different ages (5, 8, 11, 14, 21, and 21 days old). The results suggested that Kunming mice within 5 days of age were injected. Testosterone produces the best animal model for ovulation dysfunction. On this basis, 2,5,8,11,14-day-old Kunming mice were treated with testosterone, and the commonly used kidney-remedy for the treatment of menstrual disorders was separated into water-soluble and fat-soluble fractions, and each group of mice was treated with drugs. For comparison observations. Results The ovaries of the 2-day-old group were all polycystic ovary; the water-soluble part of the kidney-tonifying drugs made the uterus of each age group gain weight, hypertrophy of the interstitial gland cells of the polycystic ovary, and increased the ovary of mice over 8 days of age; Some have no effect. It is suggested that the water-soluble part of kidney-tonifying medicine is the main part of regulating ovarian function.