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目的研究白细胞介素-23(IL-23)、白细胞介素-9(IL-9)水平在支气管哮喘儿童中的变化和意义。方法采用双抗体夹心ELISA法检测30例哮喘急性发作期患儿、23例缓解期患儿和30例健康对照组患儿血清中IL-23、IL-9水平,并进行组间对比及与IgE相关性分析。结果哮喘急性发作组及缓解期组患儿血清IL-23、IL-9水平均显著高于健康对照组(P<0.01),急性发作组患儿血清IL-23、IL-9水平显著高于缓解期组(P<0.01);血清IL-23、IL-9水平均与IgE呈显著正相关(r=0.584,P<0.05;r=0.475,P<0.05)。结论 IL-23、IL-9的测定对于评价儿童支气管哮喘病情及疗效有重要意义。
Objective To study the changes and significance of interleukin-23 (IL-23) and interleukin-9 (IL-9) levels in children with bronchial asthma. Methods Serum levels of IL-23 and IL-9 in 30 children with acute asthma, 23 children with remission and 30 healthy controls were measured by double antibody sandwich ELISA. Correlation analysis. Results Serum levels of IL-23 and IL-9 in acute exacerbation group and remission group were significantly higher than those in healthy control group (P <0.01). Serum levels of IL-23 and IL-9 in acute exacerbation group were significantly higher than those in acute exacerbation group (P <0.01). Serum levels of IL-23 and IL-9 were positively correlated with IgE (r = 0.584, P <0.05; r = 0.475, P <0.05). Conclusion The determination of IL-23 and IL-9 plays an important role in the evaluation of children’s bronchial asthma.