目的　进一步评价日本血吸虫虫卵组分抗原 (10 7～ 12 1k Da)酶联免疫吸附试验 (FA-EL ISA)试剂盒的近期 (治愈后 2、4个月 )疗效考核价值。方法　非感染季节现场筛选粪阳病人 6 1例 ,分别在吡喹酮治疗前及治疗后 2、4个月做加藤氏法粪检和 FA- EL ISA、SEA- EL ISA,配对比较不同感染度病人阴转率。结果　治疗前 FA- EL ISA的检出率为 93.44 % ,SEA- EL ISA为 98.36 % ;治愈后 2个月和 4个月病人 FA- EL ISA的阴转率分别为 40 .35 %和 5 4.38% ,SEA- EL ISA则为1.6 7%和 3.33% ,两种方法间差异非常显著。 FA- EL ISA对重感染病人 (EPG>10 0 )的阴转率分别为 2 2 .2 % (2 / 9)和 33.3% (3/ 9) ,显著低于轻感染者。结论　 FA- EL ISA短程抗体诊断试剂盒对治愈后 2个月、4个月者同样有较高疗效考核价值 ,而病人的感染度似可影响阴转率 Objective To further evaluate the efficacy (2, 4 months after curative) evaluation of the kit of the antigen of the antigen of Schistosoma japonicum (10 7 ~ 12 1 k Da) by enzyme-linked immunosorbent assay (FA-ELISA). Methods Totally 61 cases of fecal-positive patients were screened in the non-infected season. Kato’s fecal semen, FA-EL ISA and SEA-EL ISA were used before and after treatment with praziquantel respectively. Negative conversion rate of patients. Results The detection rate of FA-EL ISA before treatment was 93.44%, while that of SEA-EL ISA was 98.36%. The negative conversion rates of FA-EL ISA at 40 and 35 months were 40.35% and 5 4.38 %, SEA-EL ISA was 1.6 7% and 3.33%, the difference between the two methods is very significant. The negative conversion rates of FA-EL ISA in patients with severe infections (EPG> 10 0) were significantly lower than those with mild infections (22.2%, 3/9) and 33.3% (3/9), respectively. Conclusion FA-EL ISA short-range antibody diagnostic kit for the treatment of 2 months, 4 months also have a higher efficacy evaluation value, and the patient’s infection may affect the negative conversion rate