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本文报告阿糖胞苷治疗流行性出血热的效果及免疫学变化。60例流热病人,随机分为阿糖胞苷组(第一组)、环磷酰胺组(第二组)、对照组(第三组),每组各20例进行对比观察。结果,第一组19例于治疗后24小时内体温降至正常;17例病程越过低血压期、少尿期进入多尿期,3例直越恢复期;19例于疗程结束后第一天尿蛋白阴转;20例全部治愈,经对比疗效优于第二组。三个组治疗前后细胞免疫功能 PHA 无明显变化,而 Igm 早期均上升,第一组于恢复期下降与正常组无差异,甚至两组均未下降至正常。第一组免疫复合物治前在1:20以上者10例,治疗后下降至5例,病后2～4周下降至3例,10周后为零。第一组与其它两组比较有显著差异。阿糖胞苷治疗流热疗程短(3天),无副作用,初步认为疗效满意。本文并对其药理作用进行了讨论。
This article reports the efficacy and immunological changes of cytarabine in the treatment of epidemic hemorrhagic fever. 60 cases of febrile patients were randomly divided into cytarabine group (the first group), cyclophosphamide group (the second group), the control group (the third group), 20 cases in each group were compared. Results: In the first group, the body temperature dropped to normal within 24 hours after treatment; 17 courses crossed the hypotension stage, oliguria stage entered the polyuria stage, 3 cases recovered beyond the straight line; 19 cases were on the first day after treatment Urine protein was negative; All 20 cases were cured, and the efficacy was better than that of the second group. Before and after treatment, the three groups had no significant changes in cellular immune function PHA, while the Igm increased in the early stage. The first group showed no difference with the normal group in the convalescent phase, nor did they even reach the normal level. The first group of immune complexes in the pre-rule 1:20 more than 10 cases, down to 5 cases after treatment, 2 to 4 weeks after the disease dropped to 3 cases, 10 weeks after the zero. The first group and the other two groups were significantly different. Cytarabine treatment of heat flow short (3 days), no side effects, initially that the effect is satisfactory. This article and its pharmacological effects were discussed.