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目的:观察加减血府逐瘀汤联合曲美他嗪治疗不稳定型心绞痛的临床疗效。方法:选取我院112例确诊为不稳定型心绞痛的患者,按时间顺序随机分为三组,治疗组35例,对照组A33例,对照组B34例。三组均给予常规药物治疗(硝酸类药物,β受体阻滞剂,钙离子拮抗和阿司匹林等),对照组A在常规治疗基础上每日加用曲美他嗪,对照组B在常规治疗基础上加用加减血府逐瘀汤,治疗组在常规治疗基础上予以曲美他嗪联合加减血府逐瘀汤治疗,治疗2个疗程。观察三组患者心绞痛症状、心电图等指标变化。结果:三组患者心绞痛疗效比较,治疗组总有效率(97.14%)显著高于对照组A(78.57%)和对照组B(82.35%)(P<0.05);三组患者心电图疗效比较,治疗组总有效率(94.29%)显著高于对照组A(72.73%)和对照组B(76.47%)(P<0.05);治疗28d后治疗组心绞痛发作次数和心绞痛持续时间明显优于对照组A和对照组B(P<0.05);三组治疗后,治疗组ST段回升大于0.1mm V24例,显著优于对照组A及对照组B(P<0.05),其心电图总改善率也明显优于对照组A和对照组B(P<0.05);治疗组和对照组B治疗后HDL-C、LDL-C、TG、TC四项指标均优于对照组A,比较有统计学意义(P<0.05);三组患者治疗过程未出现任何不良反应。结论:加减血府逐瘀汤联合曲美他嗪治疗冠心病不稳定型心绞痛临床效果确切,无不良反应,值得临床推广,并作进一步研究。
Objective: To observe the clinical effect of Xuefu Zhuyu Decoction combined with trimetazidine in the treatment of unstable angina pectoris. Methods: A total of 112 patients with unstable angina pectoris in our hospital were selected and randomly divided into three groups according to time sequence: 35 cases in the treatment group, 33 cases in the control group and 34 cases in the control group. The three groups were given conventional drug therapy (nitric acid drugs, β-blockers, calcium antagonists and aspirin, etc.), the control group A on a daily basis with conventional therapy with trimetazidine, the control group B in the conventional treatment On the basis of plus plus and minus Xuefu Zhuyu decoction, the treatment group was treated with trimetazidine combined with Xuefu Zhuyu Decoction on the basis of routine treatment for 2 courses of treatment. Three groups of patients with angina pectoris symptoms, ECG and other indicators change. Results: Compared with control group A (78.57%) and control group B (82.35%), the total effective rate (97.14%) in the three groups was significantly higher than that in the control group (P <0.05) The total effective rate (94.29%) in treatment group was significantly higher than that in control group A (72.73%) and control group B (76.47%) (P <0.05). The number of angina pectoris and duration of angina in treatment group And control group B (P <0.05). After treatment, the ST-segment recovery of treatment group was significantly higher than that of 0.1mm V24 group, which was significantly better than that of control group A and B (P <0.05) (P <0.05). The four indexes of HDL-C, LDL-C, TG and TC in treatment group and control group B were better than that in control group A (P> 0.05) <0.05). The three groups of patients did not show any adverse reactions during the course of treatment. Conclusion: The clinical effect of adding and subtracting Xuefu Zhuyu decoction combined with trimetazidine in the treatment of unstable angina pectoris of coronary heart disease is exact, no adverse reactions, worthy of clinical promotion, and for further study.