根据四川省矽肺治疗科研协作组要求,由我局承担二十例小檗胺治疗矽肺的临床观察任务。为确保该项任务顺利完成,在局卫生处领导下,成立了由专职医务人员参加的科研小组。负责筹备开展此项工作,于七八年十一月正式投入临床,七九年五月末结束。除一例因故治疗三个月后中断外,余十九例均按方案要求进行。现将临床观察情况小结于后。一、病例选择: 本组十九例均为经局矽肺诊断组会诊确认的单纯矽肺,未进行过任何抗矽治疗,并经临床检查无严重合并症和加杂症的男性病员。年龄45～64岁之间。一期六例、二期十例、三期三例。其中隧道开挖工十八例,隧道安砌工一例。接尘工龄为3～19年,平均接尘工龄八年零九个月。二、治疗方法: 1.药源:采用河北赤城县制药厂生产的片剂 According to the request of Sichuan Collaborative Group for the Treatment of Silicosis, 20 cases of berbamine were treated by our bureau for clinical observation of silicosis. To ensure the successful completion of this task, a scientific research team attended by full-time medical personnel was established under the leadership of the Bureau of Health. He was responsible for preparing for this work. It was officially put into clinical practice in November 1978 and ended in late May 1979. Except for one case of treatment interruption after three months, the remaining nineteen cases were conducted according to the plan. Clinical observation is now summarized in the situation. First, the case selection: The group of 19 cases were silicosis diagnosis by the Bureau of silicosis, no anti-silicon treatment, and clinical examination without serious complications and additional disease of male patients. Between the ages of 45 to 64 years. A six cases, two cases of ten cases, three cases of three cases. Among them, 18 cases of tunnel excavation workers and one case of tunnel construction workers. Dust-cleaning service for 3 to 19 years, the average dust-cleaning service length eight years and nine months. Second, the treatment: 1. Drug sources: the use of Hebei Chicheng pharmaceutical production of tablets