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目的探讨胎膜早破合并绒毛膜羊膜炎孕妇血清肿瘤坏死因子-α(TNF-α)及白细胞介素-10(IL-10)的表达及其临床意义。方法采用ELISA法测定25例胎膜早破合并绒毛膜羊膜炎孕妇(A组)、20例胎膜早破无绒毛膜羊膜炎孕妇(B组)及20例正常足月无胎膜破裂未临产孕妇(C组)血清中TNF-α及IL-10的表达。3组孕妇均于剖宫产术后留取胎膜组织行病理检查。结果 A组血清中TNF-α表达显著高于B组及C组(P均<0.05),IL-10表达显著低于B组及C组(P均<0.05)。B组血清中TNF-α及IL-10表达与C组比较差异无统计学意义(P均>0.05)。结论胎膜早破血清中TNF-α水平升高及IL-10水平降低与绒毛膜羊膜炎有关,孕妇血清中TNF-α及IL-10水平可作为评估绒毛膜羊膜炎的预测指标。
Objective To investigate the expression of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in premature rupture of membranes combined with chorioamnionitis and its clinical significance. Methods Twenty-five pregnant women with premature rupture of membranes and chorioamnionitis (group A), 20 pregnant women with premature rupture of membranes without chorioamnionitis (group B) and 20 normal without rupture of membranes The levels of serum TNF-α and IL-10 in pregnant women (group C). 3 groups of pregnant women were fetus fetus after cesarean section line of pathological examination. Results The serum level of TNF-α in group A was significantly higher than that in group B and C (all P <0.05). The level of IL-10 in group A was significantly lower than that in group B and C (all P <0.05). There was no significant difference in serum TNF-αand IL-10 between group B and group C (all P> 0.05). Conclusion Serum TNF-α and IL-10 levels in premature rupture of membranes are related to chorioamnionitis. Serum levels of TNF-α and IL-10 in pregnant women may be used as predictors of chorioamnionitis.