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目的 探讨血管内皮生长因子 (VEGF)表达与螺旋CT(SCT)表现中肝细胞癌侵袭及转移的关系。方法 对行SCT动、静脉双期扫描后经手术病理证实的 39例共 4 1个HCC病灶 ,观察其SCT表现特征。用免疫组化SP法检测肝癌组织中VEGF的表达 ,并与SCT增强特征对照。结果 VEGF蛋白阳性率为 6 1.0 % ;在转移高危组、包膜欠完整和 或无包膜组、小肝癌组中VEGF蛋白的表达均高于转移低危组、包膜完整组和大肝癌组 ,差异有显著性 (P <0 .0 5 )。结论 VEGF蛋白的表达与肝细胞癌的侵袭和转移密切相关 ,且可通过SCT增强表现在一定程度上推测VEGF蛋白的表达情况
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and the invasion and metastasis of hepatocellular carcinoma in spiral CT (SCT). Methods A total of 41 HCC lesions were confirmed by pathology in 39 patients with bilateral SCT and venous double scans. The SCT features were observed. Immunohistochemical SP method was used to detect the expression of VEGF in hepatocellular carcinoma, and was compared with that of SCT. Results The positive rate of VEGF protein was 6 1.0%. The expression of VEGF protein in small hepatocellular carcinoma group was higher than that in low metastasis group, intact capsule group and large hepatocellular carcinoma group , The difference was significant (P <0. 05). Conclusion The expression of VEGF protein is closely related to the invasion and metastasis of hepatocellular carcinoma, and it can be speculated that the expression of VEGF protein by SCT to some extent