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目的:研究深圳市劳务工乙型肝炎病毒(HBV)感染者中HBV的基因分型及临床意义。方法:应用荧光定量聚合酶链反应法(荧光PCR),对178份HBV-DNA阳性的乙型肝炎病毒感染者血清进行HBV基因分型。结果:178份血清样品中B型116份(65.17%),C型43份(24.16%),B+C混合型13份(7.30%)。男女之间平均年龄存在统计学差异(P<0.05);C型的HBeAg阳性率高于B型(P<0.05),而HBV-DNA水平低于B型,但比较无统计学意义;来自华南地区的劳务工检出HBV基因型最多。结论:深圳市劳务工流行的HBV基因型主要为B型,同时存在C型和少量的B+C混合型;HBV基因型与其致病性存在相关性。
Objective: To study the genotyping and clinical significance of HBV in labors with hepatitis B virus infection in Shenzhen. Methods: HBV DNA was genotyped in sera of 178 patients with HBV-DNA positive hepatitis B virus infection by fluorescence quantitative polymerase chain reaction (fluorescence PCR). Results: Among 178 serum samples, 116 (65.17%) were B type, 43 (24.16%) were C type and 13 (7.30%) were B + C mixed type. The average age of men and women were statistically different (P <0.05); the positive rate of HBeAg in type C was higher than that in type B (P <0.05), while the level of HBV-DNA was lower than that in type B Labors in the region detected the most HBV genotypes. CONCLUSION: The HBV genotypes prevailing among labors in Shenzhen are mainly B type, and there are C type and a small amount of B + C mixed type. The HBV genotype has a correlation with its pathogenicity.