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目的:观察国产两性霉素B对免疫功能低下患者侵袭性真菌感染(IFI)的临床疗效及安全性。方法:81例免疫功能低下合并侵袭性真菌感染患者使用普通两性霉素B,剂量为5～50mg/d,用药7～66d,平均24.5d,每位患者平均累积剂量605mg。结果:两性霉素B临床总有效率为75.7%,真菌清除率为66.7%,不良反应发生率寒战、发热58.0%,低血钾44.4%,消化道18.5%,肾功能损害14.8%。结论:国产两性霉素B抗真菌谱较广,疗效好,但须合理用药,定期监测肝肾功能、血钾水平。
Objective: To observe the clinical efficacy and safety of domestic amphotericin B in patients with immunocompromised patients with invasive fungal infection (IFI). Methods: 81 cases of immunocompromised patients with invasive fungal infection with ordinary amphotericin B, a dose of 5 ~ 50mg / d, medication 7 ~ 66d, an average of 24.5d, the average cumulative dose of 605mg per patient. Results: The total effective rate of amphotericin B was 75.7%. The fungal clearance rate was 66.7%. The incidence of adverse reactions was chills, fever 58.0%, hypokalemia 44.4%, digestive tract 18.5% and renal dysfunction 14.8%. Conclusion: The amphotericin B has a wide range of antifungal spectrum and good curative effect. However, it is necessary to rationally use amphotericin B to monitor liver and renal function and serum potassium level regularly.