自1962年以来我院使用国产他巴唑治疗甲状腺机能亢进症139例,18例发生白细胞减少(均在5000以下,10例在4000以下)其中1例发生急性关节功能障碍,今报导于下。患者冯××(住院号121412)男,17岁,学生。1979年7月11日入院。于1年前患者出现心烦易怒,心慌乏力,多汗消瘦。 临床诊断为典型甲状腺机能亢进症,自7月11日起投给他巴唑,每日30毫克,服药10天后,体温增高(37.3～38.9℃),四肢关节疼痛,搔痒,继之全身皮肤可见散在皮疹,且有抓痕。其关节疼痛难以忍受,活动受限,但关节局部无红肿,有压痛。急检白细胞4300。于7月22日停用他巴唑,并投给非那根25毫克 Since 1962, 139 cases of hyperthyroidism were treated with methimazole in our hospital, 18 cases of leukopenia (all below 5000 and 10 below 4000), of which 1 case had acute joint dysfunction. Patient Feng × × (hospital number 121412) Male, 17 years old, student. July 11, 1979 admission. A year ago, patients with irritability, palpitation fatigue, sweating weight loss. Clinical diagnosis of typical hyperthyroidism, since July 11 cast methimazole, 30 mg daily, 10 days after taking the medication, increased body temperature (37.3 ~ 38.9 ℃), joint pain, itching, followed by visible body skin Scattered, with scratches. The joint pain unbearable activity limited, but no local swelling joints, tenderness. Emergency detection of white blood cells 4300. Methimazole was discontinued on July 22 and 25 mg of phenazonium was administered