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为了分析烟草尘对卷烟厂职工恶性肿瘤死亡专率的影响，采用回顾性队列研究的方法，对河南、黑龙江两省某两卷烟厂１９８２～１９９４年间的职工进行恶性肿瘤死因分析。以队列成员中的非暴露于烟草尘组为内对照，比较两组间的恶性肿瘤死亡专率的差异。结果不论男女职工，暴露组的恶性肿瘤死亡专率均显著高于非暴露组，且可能存在剂量－反应关系。说明接触烟草尘可能是恶性肿瘤死亡的危险因素，且吸烟和接触烟草尘对恶性肿瘤可能存在协同作用。
In order to analyze the impact of tobacco dust on the mortality rate of malignant tumor in cigarette factory workers, a retrospective cohort study was conducted to analyze the causes of malignant tumor among workers in two cigarette factories in Henan and Heilongjiang provinces from 1982 to 1994. The non-exposure to tobacco dust in the cohort was used as an internal control to compare the differences in mortality rates of malignant tumors between the two groups. Results Both men and women workers, the exposed group of malignant tumor death rate was significantly higher than non-exposed group, and there may be dose-response relationship. This shows that exposure to tobacco dust may be a risk factor for the death of malignant tumors, and smoking and exposure to tobacco dust may have synergistic effects on malignant tumors.