论文部分内容阅读
目的：研究头孢克肟（Ｃｅｆ）的肠吸收特性及影响Ｃｅｆ吸收的因素．方法：采用一种改良的在体肠回流技术，对Ｃｅｆ从肠内消失速率进行研究．用反相高压液相色谱法对回流液中Ｃｅｆ浓度进行分析．结果：Ｃｅｆ主要从小肠的上部吸收，从肠中的消失速率有明显的ｐＨ依赖性．Ｃｅｆ在００１－０５ｍｍｏｌ·Ｌ－１范围内的吸收速率为一曲线．依地酸钠能够明显促进Ｃｅｆ的肠内消失速率．结论：Ｃｅｆ部分是经载体转运的，且又具有明显的细胞外转运特征
Objective: To study the intestinal absorption characteristics of Cefix and the factors influencing Cef absorption. Methods: An improved in-vivo intestinal reflux technique was used to study the rate of excretion of Cef from the intestine. The concentration of Cef in the reflux was analyzed by RP-HPLC. Results: Cef mainly absorbed from the upper part of the small intestine, and its rate of disappearance from the intestine was significantly pH-dependent. The absorption rate of Cef in the range of 001-05 mmol·L-1 is a curve. Sodium edetate can significantly promote the intestinal excretion rate of Cef. Conclusion: Cef is partly transported by carrier and has obvious extracellular transport characteristics