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目的探讨叶酸受体介导的宫颈上皮组织特殊染色(FRD)在宫颈癌筛查中的应用价值。方法对800例门诊患者行宫颈癌FRD筛查和人乳头状瘤病毒癌基因检测(HPV E6/E7);检出阳性患者行阴道镜检查和多点活检,以病理组织学检查作为金标准,比较两种检测方法的诊断效能。结果 180例患者接受了宫颈活检。FRD法的N/A病理符合率69.81%,高于HPV E6/E7法的41.51%(P<0.05);宫颈上皮内瘤变(CIN)2的病理符合率89.19%,高于HPV E6/E7法的67.57%(P<0.05)。在筛查CIN2及以上的病变中,FRD法的灵敏度与HPV E6/E7法相仿(88.76%vs.83.15%)(P>0.05),但FRD法的特异度优于HPV E6/E7法(57.14%vs.38.46%)(P<0.05)。结论在筛查CIN2及以上的病变中,FRD法的特异度优于HPV E6/E7法,且具有价格低廉和实时诊断的优点,适合用于宫颈癌的筛查。
Objective To investigate the value of folic acid receptor-mediated cervical epithelial tissue staining (FRD) in cervical cancer screening. Methods Eighty-five outpatients underwent FRD screening and HPV E6 / E7 detection of cervical cancer. Positive colposcopy and multi-biopsy were performed. The pathological examination was taken as gold standard, Compare the diagnostic efficacy of the two test methods. Results 180 patients underwent cervical biopsy. The coincidence rate of N / A pathology of FRD was 69.81%, which was higher than that of HPV E6 / E7 (41.51%, P <0.05). The pathological coincidence rate of cervical intraepithelial neoplasia (CIN) 2 was 89.19% 67.57% of the law (P <0.05). The sensitivity of the FRD method was similar to that of the HPV E6 / E7 method (88.76% vs 83.15%) (P> 0.05), but the specificity of the FRD method was better than that of the HPV E6 / E7 method (57.14 % vs.38.46%) (P <0.05). Conclusion The specificity of FRD method is better than that of HPV E6 / E7 method in the screening of CIN2 and above lesions, and it has the advantages of low cost and real-time diagnosis and is suitable for screening of cervical cancer.