目的分析2010年1月1日~2012年12月31日天津市宁河县百日咳流行病学特征及病例直接花费情况,为下一步预防和控制百日咳提供参考依据。方法利用描述流行病学方法,采用Excel 2003对2010年1月1日~2012年12月31日天津市法定传染病报告系统百日咳个案调查资料进行统计学分析,利用天津市疾病预防控制中心设计的“百日咳病例疾病负担调查表”中数据分析病例花费情况。结果 2010~2012年天津市宁河县共报告16例百日咳,平均发病率为1.28/10万;夏秋季高发,6~10月的病例占81.2%;87.5%的病例发生在农村地区;发病年龄最小的为1月龄,最大的为28岁,<1岁的病例占62.5%,发病率明显高于大龄儿童及成人;16例百日咳中,5例有免疫史,7例未到接种月龄,4例无免疫史;发病至初次就诊时间间隔中位数为13 d;11例为实验室诊断病例,5例为临床诊断病例,临床表现以痉挛性咳嗽、呕吐、口唇青紫等为主,有5例合并支气管肺炎;共有12例住院病例,二、三级医疗机构各6例,住院病例平均花费8 846元。结论农村地区百日咳发病率较高,应提高免疫服务质量并加强百日咳预防知识的宣传。婴幼儿监护人如有咳嗽等相关症状应积极就诊,降低病原传播风险。应加强百日咳的预防和控制,以减轻家庭的经济负担。 Objective To analyze the epidemiological characteristics of Pertussis and the direct case-expenditures of Pertussis in Ninghe County, Tianjin from January 1, 2010 to December 31, 2012, and provide a reference for the next step in prevention and control of whooping cough. Methods Descriptive epidemiological methods and Excel 2003 were used to carry out statistical analysis of the pertussis case-finding data of the notifiable infectious disease reporting system in Tianjin from January 1, 2010 to December 31, 2012. The data were collected by Tianjin Center for Disease Control and Prevention “Pertussis Disease Burden Survey ” in the data analysis of case costs. Results A total of 16 cases of whooping cough were reported in Ninghe County, Tianjin City from 2010 to 2012, with an average incidence of 1.28 per 100 000. In summer and autumn, 81.2% of cases were diagnosed. 87.5% of cases were in rural areas. The age of onset The smallest one month old, the largest is 28 years old, <1 year old cases accounted for 62.5%, the incidence was significantly higher than older children and adults; 16 cases of pertussis, 5 cases of immunization history, 7 cases not yet reached the age of vaccination , And no immunization history in 4 cases. The median interval from onset to initial visit was 13 days. Eleven cases were laboratory diagnosed and five cases were clinically diagnosed. The clinical manifestations were mainly spastic cough, vomiting, There are 5 cases of bronchial pneumonia; a total of 12 cases of hospitalization, secondary and tertiary medical institutions in 6 cases, the average cost of in-patient cases 8 846 yuan. Conclusion The incidence of pertussis in rural areas is relatively high, should improve the quality of immune services and strengthen awareness of whooping cough prevention knowledge. Infants and guardians cough and other symptoms should be actively treated to reduce the risk of transmission of pathogens. The prevention and control of whooping cough should be strengthened to reduce the financial burden on families.