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目的 探讨心理因素对胃窦粘膜生长抑素m RNA 阳性反应细胞的影响。方法 采用心理应激大鼠模型A、B、C三组, 以原位杂交组织化学和微机图像分析技术, 检测大鼠心理应激后胃窦粘膜生长抑素mRNA 阳性反应细胞的表达强度和细胞体积密度(Vv) 、单位体积数密度(Nv) 的变化。结果 在生长抑素m RNA 的表达程度和Vv、Nv 等方面, 三组相比, 闪光间期长短不均加电刺激组(A 组) > 闪光间期恒定加电刺激组(B 组) > 单纯闪光间期长短不均组(C组) 。结论 此结果表明, 心理应激明显增加大鼠胃窦粘膜D 细胞合成和分泌生长抑素
Objective To investigate the effect of psychological factors on gastric mucosa somatostatin m RNA positive cells. Methods Acute stress rat model A, B and C were used to detect the expression of somatostatin mRNA positive cells in antral gastric mucosa after psychological stress and in situ hybridization histochemistry and computer image analysis. Volume density (Vv), unit volume density (Nv) changes. Results Compared with the three groups, the expression level of somatostatin m RNA and Vv, Nv and so on, the average length of flash interval plus electrical stimulation group (A group)> flash interval constant plus electrical stimulation group (B group)> Simple flash interval between the uneven group (C group). Conclusions This result shows that psychological stress significantly increases the synthesis and secretion of somatostatin in gastric antral mucosal D cells