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目的研究肌醇多磷酸5-磷酸酶(PIPP)在人下咽癌中的表达,探讨其临床意义。方法对15例人下咽癌组织学标本和15例正常的癌旁组织进行免疫荧光和免疫印迹检测。结果 PIPP的表达量及荧光强度在下咽癌组织中明显低于正常组织。结论 PIPP在下咽癌组织中低表达可能为临床提供新的诊断指标。
Objective To study the expression of inositol polyphosphate 5-phosphatase (PIPP) in human hypopharyngeal carcinoma and its clinical significance. Methods 15 cases of human hypopharyngeal carcinoma specimens and 15 cases of normal paracancerous tissues were detected by immunofluorescence and immunoblotting. Results The expression and fluorescence intensity of PIPP were significantly lower in hypopharyngeal carcinoma than in normal tissue. Conclusion The low expression of PIPP in hypopharyngeal carcinoma may provide new diagnostic criteria for clinical treatment.