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目的:观察并分析高渗盐在急诊重度脑外伤并休克中的临床疗效。方法:选取我院收治的120例重度脑外伤并休克患者为研究对象,随机分为对照组与实验组,每组60例。对照组在治疗早期应用20%的甘露醇进行降颅压,实验组则在治疗早期采用浓度为7.5%的高渗盐液。结果:两组患者降颅内压的治疗效果无显著差异;在降颅压维持时间方面,实验组显著优于对照组;在维持平均动脉压基本不变时,实验组的脑灌注压、心率、尿量情况均优于对照组,两组数据差异显著,具有统计学意义(P<0.05)。结论:在重度脑外伤并休克患者的治疗中采用高渗盐液,能起到有效的复苏效果,大大降低患者的病死率,值得临床推广和应用。
Objective: To observe and analyze the clinical efficacy of hypertonic saline in emergency severe traumatic brain injury and shock. Methods: One hundred and twenty cases of severe traumatic brain injury and shock in our hospital were selected as research object and randomly divided into control group and experimental group, 60 cases in each group. In the control group, intracranial pressure was decreased by 20% mannitol in the early stage of treatment. In the experimental group, hypertonic saline solution with 7.5% concentration was used in the early stage of treatment. Results: There was no significant difference between the two groups in reducing intracranial pressure. The experimental group was significantly better than the control group in reducing the duration of intracranial pressure; while maintaining the mean arterial pressure unchanged, the cerebral perfusion pressure, heart rate , Urine output were better than the control group, the difference between the two groups was significant, with statistical significance (P <0.05). Conclusion: The use of hypertonic saline in the treatment of patients with severe brain trauma and shock can play an effective resuscitation effect, greatly reducing the mortality of patients, it is worth clinical promotion and application.