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目的探讨双水平无创正压通气(BiPAP)治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的临床疗效。方法 34例COPD合并Ⅱ型呼吸衰竭患者被随机分为对照组(n=17)和实验组(n=17),两组均给予基础治疗,实验组在对照组基础上给予BiPAP治疗方案。比较治疗前与治疗后7d两组患者的心率、呼吸、SpO2及动脉血气(pH、PaO2、PaCO2)等指标。结果两组患者治疗后7d与治疗前相比pH、PaO2及SpO2均显著升高(P<0.05),心率、呼吸及PaCO2均显著下降(P<0.05),但实验组各指标升降幅度均显著大于对照组(P<0.05)。结论 BiPAP治疗COPD合并Ⅱ型呼吸衰竭具有安全、简单、显效快、并发症少等优点,值得临床广泛推广。
Objective To investigate the clinical effect of bi-level noninvasive positive pressure ventilation (BiPAP) on chronic obstructive pulmonary disease (COPD) with type Ⅱ respiratory failure. Methods Thirty-four patients with COPD and type Ⅱ respiratory failure were randomly divided into control group (n = 17) and experimental group (n = 17). Both groups were given basic treatment. The experimental group was given BiPAP treatment on the basis of the control group. Heart rate, respiration, SpO2 and arterial blood gas (pH, PaO2, PaCO2) were compared between the two groups before and 7 days after treatment. Results The pH, PaO2 and SpO2 were significantly increased (P <0.05), and heart rate, respiration and PaCO2 were significantly decreased (P <0.05) on the 7th day after treatment in both groups. However, the indexes in the experimental group were significantly decreased Greater than the control group (P <0.05). Conclusions BiPAP has the advantages of safety, simplicity, fast onset, less complications and less complications in the treatment of COPD with type Ⅱ respiratory failure. It is worthy of extensive clinical promotion.