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Objective:To studytheeffectof glialcellline-derivedneurotrophic(GDNF)on adultperipheralnerve regeneration.Methods:Transectionedsciaticnerveinadultratswassuturedintosiliconechannel.GDNFor SALsolution wasinjectedintothesiliconechannelsduringoperation.Fourweekslater,theeffectof GDNFon axonalregenerationwas evaluatedby degenerativeneurofiberstainingandHRPretrogradetracing.Results:ComparedwithSAL group,the percentageof degenerativeneurofiberareasdecreasedfrom17.3%to1.9%(P<0.01)andtheratioof labeledspinalsomas numberwassignificantlyincreasedfrom43.5%to68.3%(P<0.01)inGDNFgroup.Conclusion:Theresultssuggestthat exogenousGDNFcanobviouslyenhanceadultperipheralnerveregeneration.
Objective: To studytheeffectof glialcellline-derivedneurotrophic (GDNF) on adultperipheralnerve regeneration.Methods: Transectionedsciaticnerveinadultratswassuturedintosiliconechannel.GDNFor SALsolution wasinjectedintothesiliconechannelsduringoperation.Fourweekslater, theeffectof GDNFon axonalregenerationwas evaluatedby degenerativeneurofiberstainingandHRPretrogradetracing.Results: ComparedwithSAL group, the percentageof degenerativeneurofiberareasdecreasedfrom17.3% to1.9% (P <0.01) and the ratio of labeled endosomally altered found from 43.5% to 68.3% (P <0.01) inGDNFgroup.Conclusion: Theresultssuggestthat exogenousGDNFcanobviouslyenhanceadultperipheralnerveregeneration.