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前年于捷克布拉格召开的国际药用高聚物讨论会上,保加利亚的伊利也夫(I.B.Iliev)等介绍一类带有氯乙胺的聚合物,实驗证明它具有抗癌功能。现根据报告內容节译介绍如下。根据前人研究,一氯乙胺(MCA,monochloroethylamine)无抗癌作用,但如果有两个或两个以上的氯乙基附在N原子时,就会有此作用。如果这些氯乙胺基团是附在同一个原子上,它的活性就很大,而毒性却很小。要是使这些氯乙胺基团间的距离加大,达到相距4～6个原子,毒性还可减少而活性不变。这是治癌药物Desranol的合成方式。作者通过共聚合与类似聚合反应制备这一类型的药物,并从实验证明其有抗癌作用。 1.通过乙烯基吡咯烷酮(VP)与氯乙酰胺的甲基丙烯酸衍生物的共聚合。所以采用VP,是由于它是水溶性的,而且无生
Two years ago at the International Medicinal Polymer Symposium held in Prague, Czech Republic, I.B.Iliev of Bulgaria introduced a class of polymers with chloroethylamine. The experiment proved that it has anti-cancer function. Now based on the contents of the report translation section is as follows. According to previous studies, MCA (monochloroethylamine) has no anticancer effect, but it will do so if two or more chloroethyl groups are attached to the N atom. If these chloroethylamine groups are attached to the same atom, its activity is great and the toxicity is minimal. If the distance between these chloroethylamine groups is increased to 4 to 6 atoms apart, the toxicity can be reduced and the activity remains unchanged. This is a synthesis of the cancer drug Desranol. The authors prepared this type of drug through copolymerization and similar polymerization reactions and demonstrated from experiments that it has an anticancer effect. 1. By copolymerizing vinyl pyrrolidone (VP) with a methacrylic acid derivative of chloroacetamide. Therefore, VP is used because it is water-soluble and non-reactive